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Energy metabolism in cows was significantly altered in early lactation, there is an increased concentration of BHB and bilirubin, a decreased concentration of glucose. Metabolism of protein is also altered so that the concentration of total protein, albumin and urea lowest in the first week after parturition, but then slowly grew. In the peripartum period, especially on the day of calving and the first days of lactation cows have fewer red blood cells and a lower concentration of hemoglobin. There is a decline in the total number of leukocytes. The aim of this study is to determine link between blood count and parameters of metabolic status of cows in early lactation. The research was conducted on 40 Holstein-Friesian cows. Blood samples were taken in the first week after calving. According to the statistical analysis, it was noticed that there was not relation between the total number of leukocytes and the metabolic status of cows in early lactation. Also, it was noticed that cows with higher values of N:L ratio, lower hemoglobin concentration and smaller number of red blood cells had higher concentration of BHB, AST and TBIL and lower concentrations of ALB. Changes in the values of metabolic parameters in a function of hematological parameters were statistically significant. Based on the above, the link between blood count parameters that indicate inflammation and metabolic adaptations in cows in early lactation is demonstrated. In further research should examine the relationship between inflammatory and metabolic parameters.