The Antarctic continent plays a fundamental role in the global climate system and its role is particularly important in a climate change scenario. Since the '90s, the Ross Sea and the coastal area of Terra Nova Bay have been chosen as specific and peculiar research sites for climatic investigations within the LTER (Long-Term Ecological Research) network. Studies have been conducted by both Italian and international Universities and research centres.This macro-site area is characterized by abundant primary productivity, and zooplankton and benthonic communities. The objective of the research activities is the acquisition of long-term time series related to the biotic communities, the bio-geochemical fluxes and the physico-chemical parameters of the water column in the Ross Sea area. To this aim, four Moorings (A, B, D and H) were deployed to obtain the above-mentioned data, which will be very useful to improve the quality of the existing bio-geochemical models and to provide more precise information on the Antarctic marine ecosystem in relation to global climate change. In the Terra Nova Bay research site, the activities are devoted to the characterization of the relationship between the structure and the dynamic of the pelagic and benthonic communities and the ice cover. Numerous physical, chemical and biological data were collected from the four Moorings, the water samples retrieved at the Terra Nova Bay site and the sediments samples. Such fundamental data allowed establishing an important starting point to better understand the climate change phenomena occurred in the last twenty years, and that will occur in the future, in the Ross Sea Area.