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Article . 2021
License: CC BY
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Article . 2021
License: CC BY
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Article . 2021
License: CC BY
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Limit of detection (LOD) in nonlinear concentration-response curves, with application in in-vitro mutagenicity assays

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2021Publisher:Zenodo
Authors: Hothorn, L.A.; Spiliotopoulos, D.; Marin-Kuan, M.; Ritz, Ch.;

doi: 10.5281/zenodo.5356885 , 10.5281/zenodo.5356884

Limit of detection (LOD) in nonlinear concentration-response curves, with application in in-vitro mutagenicity assays

Abstract

Different-shaped nonlinear concentration-response curves of various in-vitro assays can be compared by their limit of detection (LOD). To estimate an effective dose (as LOD), a nonlinear model fit and the intercept of its prediction limit with concentration 0 is used. This represents an extension of the common calibration curve LOD estimation for strict linear concentration-response curves, conditionally after suitable transformation.

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Keywords

statistics, in-vitro mutagenicity assay

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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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