The study generally aimed to determine the impact of science mentoring program as implemented in the DepEd Leyte District, Leyte Division. A total of 20 teacher-mentees from the different mentored schools were chosen as respondents of the study. Eight (8) or 40 percent were from School A, 7 or 35 percent were from School B and five or 25 percent were from School C. Out of the 20 teacher-mentees, 1 or 5 percent had a master’s degree; 7 or 35 percent had Bachelor’s degree; and 12 or 60 percent had master’s units. Data reveal that 4 teacher-mentees or 20 percent were 21 years and above in the service and were considered experienced; 8 or 40 percent were 10-20 years in service and were considered mid-career; and the other 8 0r another 40 percent were considered novice. Out of the 16 science mentoring interventions, 11 were found to be effective and 5 were less effective by the teacher-mentees. On the teacher-mentees attitude towards teaching, majority of them perceived teacher-relationship, individual difference of the learners, teaching practices and norms as more important. As to the pupils’ performance in the National Achievement Test, the Science III Mean Percentage Score of the mentored schools got the Mean of 37.11 for the school year 2007-2008 and 74.81 for the school year 2008-2009, respectively. As for the Grade VI, the mentored schools posted the Mean of 34.73 and 71.41 for the school years 2007-2008 and 2008-2009 respectively. However, in the school year 2009-2010 the result had decreased; thus, it registered a total Mean of 99.82 for the 3 school years.