This dataset is part of the supplementary data to the manuscript 'Biosynthetic potential of the global ocean microbiome', DOI to come soon (preprint available here: https://doi.org/10.1101/2021.03.24.436479). As part of this work, we established the Ocean Microbiomics Database (OMD), which can be interactively accessed at: https://www.microbiomics.io/ocean/. This repository versions some of the file that make up the database while other (larger) files can be accessed at ENA under the project PRJEB45951 (https://www.ebi.ac.uk/ena/browser/view/PRJEB45951). Metagenomic assemblies: antismash-bgcs-metagenomes-unfiltered.tar.gz: antiSMASH annotations of the metagenomic assemblies (unfiltered, i.e. includes scaffolds below 5kbp) assemblies-MGE-predictions.tsv.gz: Mobile genetic element (including plasmids, prophages, viruses etc) annotations for the metagenomic assemblies. antismash-bgcs-metagenomes-with-MGEs.tsv: Summary table combining both antiSMASH and MGE annotations. Genomes: antismash-bgcs-genomes-unfiltered.tar.gz: antiSMASH annotations of the genomes in the OMD (unfiltered, i.e. includes scaffolds below 5kbp) gecco-bgcs-genomes-summary.tsv.gz: GECCO annotations of the genomes in the OMD. antismash-bgcs-genomes-with-MGEs.tsv: Summary table combining both antiSMASH and MGE annotations for the genomes reconstructed in this study (subset of the OMD). MGE annotations are derived from the metagenomic assemblies. genomes-usage.tsv: Summary table of all the tables and their usage for the different analyses performed in this work. motus-profiles.tsv.gz: Metagenomic and metatranscriptomic taxonomic profiles. All genomes with enough marker genes were used to extend the mOTUs database, which was then use to generate these profiles. Genes: (from the OMD genomes) gene-catalog-membership.tsv.gz: Map between a gene and its representative in the 95% identity gene catalog. gene-catalog-profile.tsv.gz: Abundance profiles of the representative genes of the gene catalog. Candidatus Eudoremicrobiaceae: Eudoremicrobiaceae-profiling-raw.tsv.gz E.taraoceanii-metatranscriptomics-processed.tsv.gz Any question or further requests can be addressed as specified at https://www.microbiomics.io/ocean/ or to the corresponding authors of the associated manuscript.