Safe-by-design and EU funded NanoSafety projects is a contribution of the EU NanoSafetyCluster (NSC), supporting the SbD-study of the European Commission, March 2021 Editors: Andreas Falk, Flemming R. Cassee and Eva Valsami-Jones (NSC coordination team) This document is based on the voluntary contributions delivered by the project consortia of the projects mentioned in chapter 1 and 2. The contributions have been edited without further interpretation or commenting about those inputs. It was delivered to the European Commission to answer their request to contribute to their study on the state-of-the-art and ongoing research in the field of safe-and-sustainable-by-design. The editors kindly acknowledge the colleagues from NanoSafetyCluster community, who have contributed the information about their project to this document.