The present study aimed to analyze the human phenotypic manifestation of AB0 and Rh blood groups, descriptive features cleft in chin, freckles, hairline, eyebrow shape, dimples, earlobes and the basic characteristics of personality extraversion, agreeableness, consciousness, emotional stability and intellect/imagination and the possible relations between them. About 950 individuals were included in the study. The frequencies of the investigated phenotypic groups were calculated by usage of descriptive statistics. The results obtained were analyzed by SPSS software. Statistically significant relationships were found between some of the studied human immunological, descriptive and behavior features as follows: lower levels of emotional stability in people with Rh+ blood groups (P<0.05); higher levels of agreeableness and consciousness in people without cleft in chin (P=0.003, P=0.001) and in persons with separeted eyebrows (P=0.03, P=0.008); higher levels of emotional stability in people with straight line of hair (P<0.05); higher levels of consciousness in people without dimples and higher levels of intellect/imagination in people with dimples (P<0.05); higher levels of agreeableness and intellect/imagination in people with a free ear lobe (P=0.004, P=0.02). No statistically significant differences were detected between blood groups of the AB0 system and the presence of freckles on the face from one side and the mean values of the personality characteristics by the other hand. The present study reveals interesting relationships between various human traits based on a complex approach. It could be used as an appropriate model for other future studies of human phenotypic diversity.