Against the background of the big environmental and societal challenges as formulated for example in Flightpath 2050, current developments in aircraft design are aiming at further emission reduction through integrated, unconventional propulsion, systems and airframe innovations. This requires the further integration of methods for multidisciplinary modelling, analysis and optimization for aircraft design, but also for propulsion and system level designs. Moreover, experimental validation of the methods and physical testing of critical unconventional propulsion and system designs are prerequisites for industrially relevant development processes. This paper presents some key technologies for computationally efficient collaborative MDO (multidisciplinary design and optimization) frameworks for multidisciplinary design and validation of advanced aeronautic products like aircraft and propulsion systems.