This paper reports on the Tornidae of genus Anticlimax Pilsbry & McGinty, 1946 from the tropical Southwest Pacific, collected during the Tropical Deep-Sea Benthos expeditions conducted by IRD and MNHN in New Caledonia, Vanuatu, Fiji, the Solomon Islands, the Philippines and Papua New Guinea. Forty four species, from shallow to deep water, have been studied, with forty two being new for science. Each species is illustrated by scanning electron microscope photographs, discussing its specific variability when this is possible, and providing information about its habitat, geographical distribution and bathymetric range. Data regarding the radula and operculum are presented for the first time for the genus, regarding the species Anticlimax maranii, and so are anatomical data regarding Anticlimax cf. cyclist. Other species similar or related to this genus are studied. The genera Canimarina Aguayo & Borro, 1946 and Lioprora Laseron, 1958 are considered to be synonyms of Anticlimax. Cyclostremiscus (Canimarina) crassilabris Aguayo & Borro, 1946, Anticlimax glabra Rubio, Rolán & Pelorce, 2011 and Lioprora rostrata (Hedley, 1900), previously placed in genus Canimarina, are here transferred to genus Anticlimax. Discopsis niasensis Thiele, 1925 and Discopsis padangensis Thiele, 1925 are illustrated for the first time, new taxonomic data are reported and, together with Adeorbis carinatus A. Adams, 1863 they are transferred to genus Anticlimax.