Objective: To study lipid profile in cases of hypertension presenting at Nishtar Hospital Multan. Material and methods: This descriptive study was conducted at the Department of Medicine Nishtar Hospital Multan. From April 2018 to October 2018. A total of 100 patients admitted with hypertension were the participants of the study. The patients are in the range of 40-80 years. Both known hypertensive patients on treatment for a varying period and newly diagnosed hypertensive patients were included in the study. Results: Serum T.C., TGL, VLDL, LDL, TC/ HDL, LDL/ HDL were significantly elevated in the hypertensive group compared to healthy controls. Serum HDL was low in patients with hypertension as was compared with controls, which was statistically significant. The LDL was raised in obese compared to nonobese patients, which is statistically very significant. TC/ HDL and LDL /HDL were also raised in obese patients, which is statistically significant. T.C. is raised in the CVA group, which is statistically highly significant. LDL is raised in the CVA group, which is statistically very significant. TC/ HDL and LDL/ HDL are raised in the CVA group compared to the non-CVA group, which is statistically significant. T.C. is raised in the IHD group, which is statistically significant. LDL is raised in the IHD group, which is statistically very significant. LDL/HDL is raised in men, which is statically significant. Conclusion: There is a significant alteration of lipid profile in hypertensive patients as compared to controls. Total cholesterol, LDL cholesterol, triglycerides, VLDL, TC/HDL, and LDL/HDL ratios are significantly elevated in patients with hypertension. HDL is significantly reduced in hypertensive patients. Hyperlipidemia is seen in most hypertension cases, with the Type IIa pattern being the most frequent. Mean T.C., LDL, TC /HDL, LDL/ HDL were higher in obese. Mean T.C., LDL, TC/ HDL, and LDL/ HDL ratios are raised in the CVA group. Mean T.C. and LDL are raised in the IHD group. Keywords: Hypertension; T.C.; LDL; HDL; VLDL; TGL; Cerebrovascular accident; Ischemic heart diseases; Obesity