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</script>Objectives: To evaluate the efficacy and outcome of laparoscopic approach in the perforated peptic ulcer (PPU). Design: A Prospective and observational study. Setting and Duration: In the Department of Surgery of Mayo Hospital, Lahore for one-year duration from June 2019 to June 2020. Methodology: A total of 25 patients diagnosed with PPU were included in the study. Patients with extensive peritonitis, upper abdominal incision, in shock, or presenting 24 hours after the onset of perforation were excluded. Patients were monitored for complications. Results: Duration of the procedure: 75 minutes, patients took analgesics parenterally for 2 days, hospital stay was 5.5 days. 4 patients required conversion to the open procedure, postoperative complications were noted in 6 patients. Conclusion: Laparoscopic PPU closure is safe and has the advantages of no midline incision, little post-operative pain and a short stay in the hospital. To achieve desirable results, it is essential that Laparoscopic procedure should be done by expert surgeon or under his supervision and Careful selection of patients is crucial in curtailing conversion and complication. rate. Keywords: peptic ulcer, perforated peptic ulcer, laparoscopic closure
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