Objective: To assess factors that contribute to the development of surgical site infections in patients undergoing general surgery. Place and Duration: This research was carried out from may 2019 to april 2020 in the Surgery Department of the Nishtar Hospital in Multan. Materials and Methods: The study included patients with surgical site infections developed after general operations. Information was noted such as obesity, surgical time, hospital length, high blood pressure, diabetes mellitus, smoking and blood transfusions. Results: The study included 80 patients over 18 years of age. Around 52 per cent of patients were 45 to 60 years of age, while 15 per cent were over 60 years of age. The remaining cases ranged from 18 to 30 and from 31 to 45 years of age. The study consisted of 57 (71.25%) men and 33 (41.25%) women. Smoking (20.1 per cent), multiple blood transfusions (14.2 per cent), obesity (14.2 per cent) and lengthy hospitalization were the causes of surgical site infection (16.2 per cent). Hypertension occurred in 11.1% of patients and diabetes in 12.4% of patients. Additional 11.8% were unknown causes. Conclusion: Factors related to site infection development included multiple blood transfusions, prolonged hospital stays, smoking, obesity and emergency surgery. Key Words: SSI, Surgical site infection, General Surgery