Abstract— Mesquite (Prosopis laevigata) is a tree of arid and semi-arid areas of northern and central Mexico. This species allows erosion control, atmospheric nitrogen fixation, and improves soil quality. Pseudomonas fluorescens is a rhizobacterium that favors plant growth-promoting rhizobacteria (PGPR). Also, promotes seed germination and development of Mesquite plants under adverse environmental conditions. The aim is to evaluate the role of bacterial strains A7 and Sv of P. fluorescens, using two types of soil (vertisol and phaeozem), and adding vermicompost (0, 25, 50, 75 and 100 tons/ha) in the germination and growth stages of mesquite (Prosopis laevigata).We tested the characteristics developed by the plants over 180 days. A randomized experimental design with four repetitions was used to test the seed germination rate and 16 more variables in the greenhouse, such as morphology, dry biomass accumulated, and morphological indices through the randomized factorial experimental design with three factors, 2x3x5x3. Regarding the control treatment, the use of the bacterial strain A7 of P. fluorescens inhibited the germination of mesquite seeds, while the strain Sv favored seedlings development. We observed opposite effects; inhibition and growth in the germination stage, and development of the seedlings observed at 180 days when using the A7 and Sv strains of P. fluorescens.