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ZENODO
Dataset . 2020
License: CC BY
Data sources: Datacite
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ZENODO
Dataset . 2020
License: CC BY
Data sources: ZENODO
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BRCA1- and BRCA2- mutation associated transcriptome landscapes in breast and ovarian cancers: ml-SOM results

Authors: Arsen Arakelyan; Maria Nikoghosyan; Siras Hakobyan; Arman Simonyan; LIlit Nersisyan; Hans Binder;

BRCA1- and BRCA2- mutation associated transcriptome landscapes in breast and ovarian cancers: ml-SOM results

Abstract

This is the submission accompanying raw result files for multiple-layer SOM (ml-SOM) analysis for the paper "Transcriptome patterns of BRCA1- and BRCA2- mutated breast and ovarian cancers". The dataset contains the results of the ml-SOM analysis of RNA-sequencing data from TCGA-OV (ovarian cancer) and TCGA-BRCA (breast cancer) projects. The dataset is organized as follows: Folder "12.BC.40 - Results" - ml-SOM analysis of TCGA-BRCA (breast cancer) dataset Folder "12.OV.40 - Results" - ml-SOM analysis of TCGA-OV (ovarian cancer) dataset File "12.BC.40.RData" - R data file that contains ml-SOM environment for breast cancer File "12.OV.40.RData" - R data file that contains ml-SOM environment for breast cancer For detailed instructions on browsing the results and their interpretation please refer to the oposSOM package manual [1], as well as original publications [2-4]. References Henry Loeffler-Wirth, Hoang Thanh Le and Martin Kalcheropos. SOM.Comprehensive analysis of transcriptome data. DOI: 10.18129/B9.bioc.oposSOM Löffler-Wirth H, Kalcher M, Binder H. oposSOM: R-package for high-dimensional portraying of genome-wide expression landscapes on Bioconductor. Bioinformatics. 2015 Oct 1;31(19):3225-7. DOI: 10.1093/bioinformatics/btv342. Epub 2015 Jun 10. Wirth H, von Bergen M, Binder H. Mining SOM expression portraits: feature selection and integrating concepts of molecular function. BioData Min. 2012 Oct 8;5(1):18. DOI: 10.1186/1756-0381-5-18. Wirth H, Löffler M, von Bergen M, Binder H. Expression cartography of human tissues using self-organizing maps. BMC Bioinformatics. 2011 Jul 27;12:306. DOI: 10.1186/1471-2105-12-306.

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Keywords

multi-layer self-organizing maps, breast cancer, ovarian cancer, somatic and germline mutations, BRCA1, BRCA2, transcriptome portrayal

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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