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Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T cell memory formation after mild COVID-19 infection

Research datakeyboard_double_arrow_right Dataset 20 May 2020Publisher:Zenodo

Authors: Anastasia A. Minervina; Ekaterina A. Komech; Aleksei Titov; Meriem Bensouda Koraichi; Elisa Rosati; Ilgar Z. Mamedov; Andre Franke; +6 Authors

doi: 10.5281/zenodo.3835956 , 10.5281/zenodo.3835955 , 10.5281/zenodo.4065547

Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T cell memory formation after mild COVID-19 infection

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Abstract

Processed TCRbeta and TCRalpha repertoires after mild COVID-19 infection, see preprint: https://www.biorxiv.org/content/10.1101/2020.05.18.100545v1 and GitHub repository: https://github.com/pogorely/Minervina_COVID Two donors (M and W), two biological replicates of PBMC (F1 and F2), CD4+, CD8+, and Memory subpopulations for each post-infection time points (day 15, 30, 37, 45 post-infection), and pre-infection PBMC repertoires sampled in 2019 and 2018.

Demultiplexing and UMI-consenuses were done with migec (v. 1.2.7), alignments and assembly of UMI-consensuses into clonotypes performed with mixcr (v. 2.1.11).

Related Organizations

French National Centre for Scientific Research
France
Sorbonne Paris Cité
France
Federal State Institution Hematology Research Center
Russian Federation
University of Paris
France
Kiel University
Germany

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Keywords

RepSeq, TCR, COVID

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