The European Open Science Cloud (EOSC) will “enable a trusted, virtual, federated environment in Europe to store, share and reuse digital outputs from research (including publications, data, metadata and software) across borders and scientific disciplines”1. Today, at the end of 2020, many building blocks are in place and on-going EOSC projects endeavour to enrich the EOSC ecosystem. To ensure strong engagement by research communities, we believe that this is the time to re-orient the EOSC activities towards higher relevance for these communities. The Science Clusters ENVRI-FAIR , EOSC-LIFE , ESCAPE , PaNOSC , SSHOC bring together 72 world-class research infrastructures from the ESFRI roadmap and beyond to work on FAIR data management and connecting their user communities to the EOSC. The European e-infrastructures EGI , EUDAT , GÉANT , and OpenAIRE provide inclusive services across Europe and beyond to the benefit of science.