In most of the cases the decision to invest in a transport infrastructure is not simple, mainly, because the complications in planning process, the amount of capital need to invest before the business establishment and the high number of stakeholders involved in decision process. The decision process is more complicate in large transport infrastructures, where the project survivability strongly related to regional development prospects and the transport business targets in medium-long time horizon. Also, different expectations from authorities and stakeholders lead to significant conflict between authorities and local communities about the advantages and disadvantages to develop large transport infrastructure projects. This paper deal with the methodology approach to support strategic decisions about develop a new large transport infrastructure project. According a systematic approach, the analysis framework where the decision key issues are evaluated and the key messages to decision makers are presented. Conventional wisdom is to present a systematic approach appropriate to apply is relevant projects, providing the essential tool to support decisions at level of strategic planning. This paper attempts to fill gaps faced by stakeholders and decisions makers in the evaluation and decision making process of developing large transport infrastructure projects.