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Identification of immunodominant linear epitopes from SARS-CoV-2 patient plasma

Authors: Lluc Farrera-Soler; Jean-Pierre Daguer; Sofia Barluenga; Oscar Vadas; Patrick Cohen; Sabrina Pagano; Sabine Yerly; +3 Authors

Identification of immunodominant linear epitopes from SARS-CoV-2 patient plasma

Abstract

A novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) is the source of a current pandemic (COVID-19) with devastating consequences in public health and economic stability. Using a peptide array to map the antibody response of plasma from healing patients, we identified immunodominant linear epitopes corresponding to key proteolytic sites on the spike protein.

Country
Switzerland
Keywords

Peptide Nucleic Acids, Science, Pneumonia, Viral, Protein Array Analysis, 610, Antibodies, Viral, Betacoronavirus, Epitopes, 616, Humans, Amino Acid Sequence, Pandemics, Furin, SARS-CoV-2, Q, R, COVID-19, 540, Recombinant Proteins, Protein Structure, Tertiary, Proteolysis, Spike Glycoprotein, Coronavirus, Medicine, Coronavirus Infections, Peptides, Sequence Alignment, Epitope Mapping, Research Article, ddc: ddc:610, ddc: ddc:616, ddc: ddc:540

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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OpenAIRE UsageCountsViews provided by UsageCounts
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