Rheumatoid Arthritis (RA) is an auto immune disease that affects in the clinical manifestations of arthritis in each patient. In addition to the development of medication, the clinical manifestations are to achieve the most effective role with less side effects by improving the pharmacokinetic and pharmacodynamic profiles. Multiple environmental factors including hormones, dietary factors, infections and exposure tobacco smoke as well as associated with increased risk for rheumatoid arthritis. Concurrently have proven in effective by retaining the therapeutic index at synovial cavity by virtue of its diagnostic medication. Current trends and future perspectives imply that definitive role in drug release are controlled by biological modifications in the anti-rheumatic drugs behaves the significant characteristic in achieving the disease remission without joint deformity.