Background: The consumption of alcohol is part of the cultural diet, but its regular, excessive, or even abusive intake results in dysfunctions of several kinds. Among these alcohols, there are local alcohols that are highly appreciated and therefore excessive consumption has become a tradition. We also know that the metabolism of this product generates the production of metabolic markers, in this case, transaminases (aspartate aminotransferase (ASAT), alanine aminotransférase (ALAT) or gamma (GT) are indicators of toxicity. Objectives: To assess the danger or toxicity of these alcohols, a cross-sectional study was carried out. The aim of the study is to quantify and compare the serum values of transaminases (GGT, ASAT, ALAT) in different regular consumers of local alcohol in a population of Libreville. A cross-sectional observational survey on a sample of 116 people regardless of gender was carried out beforehand. Biological analyzes were carried out at the National Public Health Laboratory. Material and Methods: Analysis of the results showed that local wines strongly influence the secretion of transaminases as GGT, ASAT, ALAT are 2 to 3 times higher compared to other alcohols and it shows how often this local wine is toxic for the organization. These results also show that almost 40% of people over the age of 50 indulge in the consumption of local drinks. This observation is supported by the attractiveness of the prices charged. These drinks would, therefore, be more accessible and within the reach of all budgets. Conclusions: These results indicate that the excessive consumption of alcohol, regardless of their origin causes a high production of transaminases by the liver. These biomarkers are indicators of proven metabolic dysfunctions, more serious with age.