Background: Breast cancer is the second leading cause of cancer death in women (only lung cancer kills more women each year). The chance that a woman will die from breast cancer is about 1 in 38 (about 2.6%). Aim: To evaluate the effectiveness of structured educational programme on knowledge and practice regarding breast cancer and breast self-examination among the B.Ed. students studying in Shivaji College of Education, Karwar. Method: An evaluative approach with pre experimental pre-test-post-test design was used for the study. Forty two B.Ed. students were selected by purposive non probability sampling method based on inclusion criteria. The structured knowledge questionnaire is prepared to assess the knowledge related to breast cancer and breast self-examination and an observation checklist is prepared to evaluate the practice of breast self-examination. The questionnaire consists of eight items to obtain socio demographic data, and forty items to assess the level of knowledge regarding breast cancer and breast self-examination. A structured educational programme was prepared and administered regarding breast cancer and breast self-examination after conducting pre-test to the students. Post-test was conducted after six days of administration of structured educational programme. The data collected was analysed using descriptive and inferential statistics. Result: The findings revealed that the pre-test knowledge scores of B.Ed. students were 54% (average knowledge) and 46% (poor knowledge) and the post-test knowledge scores were 17% (good knowledge), 79% (average knowledge) and 4% (poor knowledge) respectively. The distribution of practice scores for B.Ed. students includes pre-test practice scores i.e. 4% (average practice) and 96% (poor practice knowledge) and the post-test practice scores were 11% (good practice), 75% (average practice) and 14% (poor practice) respectively. Conclusion: The study findings revealed that there was significant increase in knowledge and practice level of B.Ed. students after administration of the structured educational programme.