These are image tiles of tumor tissue of N=604 colorectal cancer (CRC) histological whole slide images in the TCGA database. The tumor tissue was manually outlined and cut into non-overlapping tiles of 512x512 px at 0.5 µm/px. No further preprocessing was applied. No color normalization was applied. Tiles are compressed with JPEG. Each ZIP file corresponds to one whole slide image (original format: SVS). Please cite our previous publication related to this dataset: https://www.nature.com/articles/s41591-019-0462-y Please observe the original TCGA licenses if you use the data https://portal.gdc.cancer.gov/ Original image credit to TCGA: https://portal.gdc.cancer.gov/ Image tiles were created with QuPath v0.1.2 https://qupath.github.io Genetic data matching these images are available at https://cbioportal.org More information on the procedures: https://zenodo.org/record/3694994