Ethnobotanical knowledge plays an important role in curing various diseases among the indigenous people in and around the north-east India. An ethnobotanical study of medicinal plants was carried out in fringe villages at Manas National Park in Baksa district, Assam from 10th October, 2018 to 8th February 2019. During this survey a total of 33 plants species belonging to 24 families has been recorded in the study area. The present study focused on documentation of medicinal plants used to treat various human diseases such as diarrhea, dysentery, pain, kidney stones, diabetes and liver disorder etc. The study is an attempt to understand the plants used as medicine amongst the ethnic people and to attract their heedfulness on needful oonservation of medicinal plants in the study area.