Levitsky A. P., Khodakov I. V., Batig V. M., Selivanskaia І. A., Markov A. V., Lapinskaia A. P. LIPOSAN FORTE – IS A NEW STABILIZED PRODUCT OF ESSENTIAL POLYUNSATURATED FATTY ACIDS. ВІСНИК МОРСЬКОЇ МЕДИЦИНИ. 2019;4(85):111-118. ISSN 0049-6804. DOI http://dx.doi.org/10.5281/zenodo.3608265 http://www.herald.com.ua ЛИПОСАН-ФОРТЕ – НОВЫЙ СТАБИЛИЗИРОВАННЫЙ ПРЕПАРАТ ЭССЕНЦИАЛЬНЫХ ПОЛИНЕНАСЫЩЕННЫХ ЖИРНЫХ КИСЛОТ А. П. Левицкий1, И. В. Ходаков1 В. М. Батиг2, И. А. Селиванская1, А. В. Марков3, А. П. Лапинская4 1ГУ «Институт стоматологии и челюстно - лицевой хирургии НАМН Украины», г. Одесса; 2Буковинский государственный медицинский университет, г. Черновцы; 3Львовский национальный медицинский университет им. Данилы Галицкого; 4Одесская национальная академия пищевых технологий LIPOSAN FORTE – IS A NEW STABILIZED PRODUCT OF ESSENTIAL POLYUNSATURATED FATTY ACIDS Levitsky A. P., Khodakov I. V., Batig V. M., Selivanskaia І. A., Markov A. V., Lapinskaia A. P. SE «The Institute of Stomatology and Maxillo-Facial Surgery of the National Academy of Medical Science of Ukraine», Odessa; Bukovina State Medical University, Chernovtsy; Lviv National Medical University named after Danylo Galytskij; Odessa national academy of food technologies; E-mail: flavan@mail.ru. Summary. Aim: To present the characteristics of a new preparation of essential polyunsaturated fatty acids (PUFAs) “Liposan-forte”. Materials and methods: The composition of fatty acids in the preparation and in serum lipids was determined by gas-chromatographic method. The presence of inflammation in the liver and serum was evaluated by the level of elastase activity and the content of malondialdehyde (MDA). Assessment of nutritional value was carried out on rats. Results: The formulation of the oil solution of the Liposan-forte drug was developed by combining fish oil and a solution of tocopherol and β-carotene in high oleic sunflower oil in a ratio of 1: 2. The drug has a ratio of ω-6/ω-3 PUFA less than 0,6, does not cause inflammation and does not activate lipid peroxidation. Increases the content of ω-3 PUFAs, improves the ratio of ω-6/ω-3 PUFA. Conclusion: One tablespoon of the drug "Liposan-forte" provides the daily human need for ω-3 PUFA. Key words: PUFA, preparation of PUFA, ratio ω-6 / ω-3 PUFA, biological effect of PUFA.