Background: Fried food is consumed worldwide because it is fast, delicious, and available everywhere. However, many studies suggested that fried food consumption promote many risks on health such as obesity, cardiovascular diseases (CVD), type 2 diabetes (T2DM) and cancer. Objective: To discuss health hazards effect of fried food and its relation to chronic diseases. In addition, to raise the awareness of the society about the risks of frequent consumption of fried food on health. Method: By using Pubmed search, Scholar search and The American Jornal of Clinical Nutrition. Searching for (fried food risk- fried food and cancer- -fried food and diabetes- -fried food and obesity- fried food and CVD- fried food and cholesterol- fried food and cardiac disease). Conclusion:This review article showed that frequent fried food use (≥4 times/week is associated with a high risk of having a chronic disease such as: obesity, type 2 diabetes mellitus, myocardial infarction, hypertension and cancer. Therefore, it has been suggested that fried food should be avoided as possible in order to decrease the risk of such chronic health problems and future researches should be focusing on these problems and try to develop better assessment for fried food consumption.