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Industry 4.0 is subset of ‘forth industrial revolution’ also it is now days known as ‘smart manufacturing’, ‘industrial internet’ or ‘integrated industry’. This paper seeks to discuss the opportunities of Industry 4.0 in the context of zero defect manufacturing, since the implications are expected in this field. We are pursue the goal to light up the topic which is handled and still need grab more attention towards it on Industry 4.0 in the context of zero defect manufacturing, thus the following research paper approach. It addresses intelligence and sustainable production achieved through combination and integration of online predictive maintenance, monitoring of processes parameters and continuous quality controls of both input materials and output from the process.