In the North Caucasus, neoascaridosis of calves (among nematodoses of the digestive tract of young cattle) is a poorly understood disease. However, this pathology in calves is found with an invasion extensity of 6 to 28%, which requires the development of new methods of therapy and prevention using new domestic complex preparations. In experiments with group prescribing, the new multidisperse anthelmintic drug Fenbental granulate 10% at a dose of 20 mg / kg body weight, mixed with food 1: 100, showed EE -87, 50% and IE – 91, 10% and at a dose of 30 mg / kg body weight, mixed with food 1: 100, showed EE -100% and IE – 100% is recommended as an effective of means neoascaridosis calves. Fenbental granulate 10% of at a dose of 30 mg / kg body weight during commission tests was showed EE 90, 00% with an IE of 92,40%. Albefen granulate 10% experimentally and in commission experiments is a highly effective drug and is recommended for the treatment and prevention of calves neoascaridosis by individual and group methods of with food. Keywords: calves; invasion; neoascaridosis, Fenbental granulate 10%; extensefficiency; Intensefficiency.