The study investigated determinants of family background variables on the career choice of secondary school students in Ekiti State, Nigeria. The purpose of the study is to determine which of the family background variable that influences the career choice of secondary school in Ekiti State. To also find out the degree at which each of the variables influences the career choice of these students. Two questions were raised to guide the study with one null hypothesis. Descriptive of survey design was employed in the study. The population was all senior secondary school students where 500 students were sampled through stratified and Simple Random Sampling Methods. A self-designed instrument named family background variables and career choice questionnaires (FBVCCQ) was used to collect relevant information. The instrument was validated through test-retest with the reliability coefficient of 0.78. The instrument was administered and collected immediately. The collected data were analysed using frequency counts and percentage, ANOVA was used to test the only one hypothesis formulated. The results revealed that family background variables generally have an influence on the choice of career among the secondary school students in Ekiti State. The study suggested that career program should be put in place by the counselling unit in the school to help these students in preparing for their future.