This paper introduces an Autonomous Smart Sensing Card (ASSC), an embedded system that will be powered indoors and outdoors by harvested energy, have miniaturized dimensions and serve multi-sensorial IoT applications for smart living and working environments. It will consist of a combination of newly developed and optimized off-the-shelf or close-tocommercialization technologies such as PV harvesters, energy storage and power management units, MCUs and sensors, all packed with a form factor under 3mm in thickness. The system will introduce technical breakthroughs that will boost further miniaturization, a small footprint, ultra-low power consumption as well as short- and long-range communications.