The Institut Français de Bioinformatique (IFB) is one of the 22 French national research infrastructures that have been created to address these challenges in the context of the Programme Investissement d’Avenir (PIA) launched by the Research Ministry in 2010. IFB began to operate in summer 2013. Following the midterm evaluation report (autumn 2016), a new work plan was prepared under the co-leadership of Claudine Médigue (Research Director at the Centre National de la Recherche Scientifique) and Jacques van Helden (Professor at Aix-Marseille University). The plan was submitted for external evaluation, and the revised version was definitively validated in May 2018. The current report describes the results achieved by IFB in the context of this restructuration.