This study aimed at determining the relationship between Management of Innovative Supervision and Teachers? job Effectiveness in Secondary Schools in Calabar Municipality Area of Cross River State, Nigeria. Two research questions were stated to direct this study. The study adopted descriptive survey. The population of this study consists of two hundred and sixty five (265) teachers in sixteen public secondary schools. Simple random sampling technique was adopted, through the ?hat? and ?draw? method. A sample size of one hundred and sixty teachers, were selected. Questionnaire titled Management of Innovative Supervision and Teachers Job Effectiveness Questionnaire (MISTJEQ) was used for data collection. The instrument was validated and a reliability estimate of 6.72 and 7.16 was obtained using cronbach alpha. Mean and standard deviation were used for data analysis. The result of the study showed a positive influence of management of innovative supervision in terms of mentoring approach and school based workshop on teachers? job effectiveness. It was recommended that school principals and the Ministry of Education should ensure regular, constant training and retraining programs through mentoring, classroom observation, workshop and conferences, as these will enhance teachers? job effectiveness and improve students? academic performance.