Subject of the study – the state regulation mechanism of the Ukrainian regions development that corresponds to global transformations trends requirements. The purpose of the study is to formulate methodological framework, which will contribute to the implementation of European standards in the practice of planning and strategic management of the Ukrainian regions development. Methodology of the study are the standards of the «Classification of Territorial Units for Statistics, (NUTS)», which are proposed to be implemented in accordance with the realities of the Ukrainian national economy. The main result of the study is an appropriate mechanism for the state regulation mechanism of the Ukrainian regions development that corresponds to global transformations trends, a key element of which is the European geostandard (NUTS). Keywords: development, region, European Classification of Territorial Units for Statistics (NUTS), regional policy, strategy, regional development strategy. The article is devoted to the development of conceptual foundations needed for the formation of a mechanism to be used for state regulation of the Ukrainian regions development, which has to be consistent with the trends of global transformations. It is proved that in Ukraine does not exist now the system of effective regionalization of the country’s territory that would meet European standards of territorial distribution and statistical accounting. As a result, the current administrative and territorial division does not take into account the features of territories, as well as the newly created territorial communities, etc., and does not coordinate their functioning with the strategic development goals of the country as a whole. This impedes the successful integration of Ukraine into the world economic space, the implementation of the strategic vision of sustainable social and economic growth vector into regional development planning practice, which would allow the systemic transformation process with the rational use of available resources and gradual movement in the direction desired by society. The implementation of this condition requires the introduction of the systemic strategic planning into the practice of public administration, which should help to eliminate the fragmentation of state regulation of the regional development, the declarative nature of adopted program documents, as well as their inconsistency among themselves. Conclusions. It is emphasized that in order to approximate the planning and management system for the development of territories to international standards, special attention should be focused on adapting the distribution system and statistical accounting of the Ukrainian regions to European standards. In this context, it has been proved that the NUTS system, which is a European geocoding standard developed by the European Commission, should be developed and introduced into practice in the country.