Proceedings of the 6th Iranian Congress of Nutrition 24-27 February 2000, Ahvaz University of Medical Sciences, p. 6 Abstract: Cardiovascular diseases and cancers are now the leading cause of death in developed countries. In most industrialized countries, coronary heart disease causes 25 to 30 percent of deaths. Reducing the attenuation of coronary heart disease is attributable to lifestyle changes and associated risk factors (such as diet, cholesterol and serum lipids, smoking, physical activity, and hypertension). This study is a quasi-experimental study performed in 1999 to determine the effect of health education on blood lipids level of hyperlipidemic patients in Isfahan. In this study, 102 patients (Range of age 28-77 years, mean age 43.9 11 11.7) were selected by simple sampling method and divided randomly into two groups (n = 59) and control (n = 43). Baseline data were collected by a multivariate questionnaire (demographic information, physical status, and KAP assessment questions) and TG, T.Chol, LDL, HDL in both groups. Then the health education program was administered in the experimental group. After gathering the final data, the data were analyzed by Chi-square, paired t-test, and independent t-test. The results showed a positive effect of education on decreasing TG (P = 0.001), T.Chol (p = 0.001), LDL (P = 0.005) in the experimental group in comparison of control group but there is no significant effect on HDL (P = 0.22). Also, the knowledge, attitude and practice of the experimental group was significantly higher than the control group after the education program (P = 0.001). It seems that the health education is one of the most effective and appropriate methods for controlling and treating hyperlipidemia and ultimately preventing coronary heart disease. Keywords: Health education, Blood lipids, Hyperlipidemia, Knowledge, Attitude, Practice