The quantum space is both an important part of quantum mechanics and the core problem in the philosophy of quantum mechanics. Because the quantum objects, such as electron and photon, always moves at the speed close to that of light, it is inevitable to involve the inseparability between space and time and discuss the 4-dimensional space-time. In order to investigate the essence of space-time, we must approach to the realm of physical philosophy and discuss the core problem, i.e. the realism in the space-time theories. In this paper, we, combined the semantic and contextual analysis, analyze the development of realism in the development of quantum space-time theory.