A field experiment was conducted at Teaching and Research Farm, Adamawa State University, Mubi, in the Northern Guinea Savanna of Nigeria during the 2017 growing season June to December 2017, to investigate the response of tiger nuts (Cyperus esculentus L.) to NPK, Cattle dung and Poultry droppings with the objective of selecting the best fertilizer combinations that can boost the yield of tiger nut. The treatments consisted of T1=240kgha-1 NPK, T2= 240kgha-1 Poultry droppings (PD), T3= 480kg-1 Cow dung (CD) T4=177.5kgha-1 NPK+62.5kgha-1 Poultry droppings (PD), T5=177.5kg-1 NPK +302.5kg-1 Cow dung (CD) T6=100kgha-1 NPK+ 140kgha-1 Poultry droppings (PD)+240kg-1 Cow dung (CD) T7= Control (no fertilizer treatment). The experiment was laid out in a Randomized Complete Block Design (RCBD), in three (3) replicates data was collected on Plant height, Number of leaves, Days of 50% flowering, Days to 90% maturity, Number of tuber per plant, 100 tuber weight, tuber yield per plot and tuber yield kg/ha. Data collected was subjected to Analysis of Variance (ANOVA) using MINITAB computer software program, significant means were separated using Duncan Multiple Range Test (DMRT) at P ≤ 0.05. Simple Pearson correlation was also conducted to show the relationship between these observed characters to yield. The result revealed that, the soil treated with the mixture of 100kgha-1 NPK+ 140kgha-1 Poultry droppings (PD)+240kg-1 Cow dung (CD) recorded the fastest growth, yielded the highest number of leaves, produced the heaviest tuber weight, highest number of tuber per plan, tuber yield per plot and tuber yield in Kgha-1 compared with the other treatments. The findings from this research revealed that a mixture of 100kgha-1 NPK+ 140kgha-1 Poultry droppings (PD) + 240kgha-1 Cow dung is the best fertilizer combination and rate that can enhance the yield of tiger nut. Significant positive correlation between tuber yield and plant height number of leaves, hundred tuber weights, number of tuber per plant, and tuber yield per plant suggest that increase in these characters will lead to increase in tuber yield of tiger nut, hence these are important characters to be considered when planning for hybridization involving tiger nut for yield improvement.