One of the most common diseases at present is the cancer that affects any member of the human body such as kidney tissue. Nuclear medicine is important in the examination and treatment, which uses a lot of particles in treatment such as Alpha particle. Alpha particles have a distinctive and important characteristic in the radiation therapy of the target part (the injured). This characteristic is due to its high ability to ionize the substance (the tissue) as it passes through, making their path short. However, there are many problems in radiation therapy; including damage to the area surrounding the tumor (the affected area) so it is very important to regulate the radiation carefully and accurately. In the present study, the study of the interaction of alpha particles with kidney tissue where the stopping power of the alpha particles was calculated using two methods: Zigler formula and SRIM software also the Range and liner energy transfer (LET) and kidney tissue thickness as well as Dose and Equivalent Dose for this particle were calculated by using Mat lab language for (0.001-1000)MeV alpha energy.