Effective science instructors can easily form a bridge between the learner and the subject matter to facilitate learning that link the learner into a science oriented society. Instructors are a chief input into the higher production process. A poorly prepared teacher can hamper the effectiveness of any carefully selected and well-organized instruction through indifferent and negative attitudes. This study aimed to assess the instructors’ effectiveness of instruction in terms of: commitment, knowledge of the subject, teaching for independent learning, and management of learning. Results showed that instructors’ effectiveness in terms of commitment, knowledge of the subject, teaching for independent learning and management of learning are important determinants of students’ performance. Overall findings suggest that further studies pertaining to qualities of effective instructors as perceived by university students be conducted to enhance teaching and learning in higher education.