The acceptance sampling plans are one of the most important tools for the inspection of a lot of products. Sometimes, it is difficult to study the variable of interest, and some additional or auxiliary information which is correlated to that variable is available. The existing sampling plans having auxiliary information are applied when the full, precise, determinate and clear data is available for lot sentencing. Neutrosophic statistics, which is the extension of classical statistics, can be applied when information about the quality of interest or auxiliary information is unclear and indeterminate. In this paper, we will introduce a neutrosophic regression estimator. We will design a new sampling plan using the neutrosophic regression estimator. The neutrosophic parameters of the proposed plan will be determined through the neutrosophic optimization solution. The efficiency of the proposed plan is discussed. The results of the proposed plan will be explained using real industrial data. From the comparison, it is concluded that the proposed sampling plan is more effective and adequate for the inspection of a lot than the existing plan, under the conditions of uncertainty.