The study was undertakento assess the effectiveness of structured teaching programme on knowledge regarding psychological symptoms of depression among menopausal women. The research design used for this study was quantitative experimental research design. The result shows that majority of the samples 24(40%) had inadequate knowledge, 35(58.4%) had moderate knowledge, 1(1.6%) had adequate knowledge during pre test, But after the structured teaching programme during the post test, majority of the samples 55(91.7%) had adequate knowledge, 5(8.3%) had moderate knowledge and none of them had inadequate knowledge. The result revealed that after structured teaching programme the level of knowledge was increased which was evidenced by improved post test level of knowledge score. The obtained ?t? value was 21.8 was more than the table value and significant at p < 0.05 level. Hence the stated hypothesis was accepted and it was informed that structured teaching programme was effective in improving the knowledge level of psychological symptom of depression among menopausal women