In the paper there has been studied the process of wine making from local grape varieties: Feteasca White, Feteasca, Regala, Feteasca Neagra, Rara Neagra, in conditions of microvinification. Wine raw materials were obtained with the involvement of a dynamic process of alcoholic fermentation from the varieties harvested in different regions of the Republic of Moldova. It has been established that the obtained wine material meets the requirements of the normative documents. The organoleptic characteristics of the red and white wines produced from the local varieties in the micro winery of the Technical University of Moldova are specific to each grape variety and they are of the highest quality.