This paper aims to determine the MIS unit’s operational status and the performance level of information systems of the state universities and colleges in the Samar-Leyte Islands. In order to determine and appreciate the value and importance of MIS unit’s services, the unit requires a review of its profile and ICT resources. The theory of Information System success model of DeLone and McLean was then used for evaluation to measure the performance and effectiveness of IS in terms of system, information, service quality, use (intention to), user satisfaction and net benefits. The profile of MIS units identified each its capacity and characterized the performance and quality of IS.