Mediterranean climates are characterized by long periods of drought during summer and short dry periods from autumn to spring, what limits plant CO2 assimilation and biomass production to a great extent. The JRC has set a series of thresholds to define marginal lands in terms of biophysical constraints. We focus on climate limitation given by the ratio between precipitations and potential evapotranspiration (P/ET). Areas with P/ET ≤0.60 are classified as affected by “dryness”. The present study follows up a long-term plantation of the C4 perennial grass Saccharum spontaneum ssp. aegypticum under different water regimes in a semi-arid Mediterranean environment.