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Other literature type . 2026
License: CC BY
Data sources: ZENODO
ZENODO
Data Paper . 2026
License: CC BY
Data sources: Datacite
ZENODO
Data Paper . 2026
License: CC BY
Data sources: Datacite
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Variasi mtDNA terhadap Penurunan Efisiensi Produksi Energi dan Peningkatan Resistensi Insulin Menggunakan Hewan Model Obesitas

Authors: Putri Lestari, Nindia;

Variasi mtDNA terhadap Penurunan Efisiensi Produksi Energi dan Peningkatan Resistensi Insulin Menggunakan Hewan Model Obesitas

Abstract

kajian integrasi bidang spesifik biologi antara genetika molekuler, fisiologi hewan dan fisiologi tumbuhan memberikan pendekatan yang komprehensif untuk mendapatkan informasi mengenai diabetes melitus tipe 2. Variasi mtDNA khususnya gen yang berperan dalam rantai transpor elektron seperti COX3, ND4, CYTB sangat berperan dalam penurunan efisiensi produksi ATP, peningkatan stress oksidatif serta yang paling berefek yaitu mengganggu sinyal insulin yang mengakibatkan resistensi insulin dan berakhir menderita diabetes melitus tipe 2. Penggunaan hewan model obesitas efektif untuk mengungkap hubungan sebab-akibat antara variasi mtDNA dengan perubahan fisiologis tubuh dan membantu dalam penemuan biomarker untuk diabetes melitus. Kolaborasi dengan fisiologi tumbuhan membantu dalam menemukan potensi tanamana yang mengadung senyawa aktif yang mampu memperbaiki homeostatis tubuh dan berperan sebagai antidiabetes. Integrasi ketiga bisang biologi ini selain menemukan biomarker baru, juga menjadi kajian untuk pencegahan dan deteksi dini penyakit/kelainan yang efektif.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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