The report provides an overview of two workshops: 1)The workshop “Systems biology and its impact on science, economy, individuals and society” took place in Ljubljana, Slovenia, on October 17, 2014. To this free three-hour workshop teachers at all levels of education system, representatives of ministries and pharmaceutical industry, medical doctors, media and others were invited. At the workshop it was shown how new knowledge obtained by using systems biology approaches has already contributed to new solutions in biotechnology, health, pharmacy, agriculture and environment. The official language of the workshop was Slovene and the information was presented on the level acceptable for the general public. For the workshop the informational printed material was prepared and the information about SB in Slovene was released on-line. The workshop was a event linked with the 9th CFGBC Symposium “From arrays and sequencing to understanding diseases”. As such this workshop is a model that can be easily transferred also to other environments across Europe and can serve as an efficient mean to raise awareness and understanding of systems biology in general public. 2) The ISBE/C4Sys international workshop on systems biology was held in Nové Hrady, Czech Republic on June 18, 2014 and was organized within the 4th Visegrad Symposium on Structural Systems Biology held at the Institute of Nanobiology and Structural Biology, Global Change Research Centre, Academy of Sciences of the Czech Republic. The whole 3-day symposium was organized by universities from the Visegrad 4 (Poland, Slovakia, Hungary and Czech Republic).