Powered by OpenAIRE graph
Found an issue? Give us feedback
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
ZENODO
Preprint . 2026
License: CC BY
Data sources: ZENODO
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
ZENODO
Preprint . 2026
License: CC BY
Data sources: ZENODO
ZENODO
Preprint . 2026
License: CC BY
Data sources: Datacite
ZENODO
Preprint . 2026
License: CC BY
Data sources: Datacite
ZENODO
Preprint . 2026
License: CC BY
Data sources: Datacite
versions View all 3 versions
addClaim

Intensity and Visual Content Dissociate in DMT: Dynamic Integration-Complexity Predicts One, Spatial Configuration the Other

Authors: Dobbin, Emma;

Intensity and Visual Content Dissociate in DMT: Dynamic Integration-Complexity Predicts One, Spatial Configuration the Other

Abstract

Abstract Background. The intensity and content of conscious experience are theoretically separable, but rarely dissociated empirically within one dataset using EEG. Existing consciousness measures typically capture level or state without addressing content, or decode content without indexing intensity. No existing measure tracks the dynamic rate of integration-complexity reconfiguration. Results. We introduce mac_I (mean absolute change of CGI, where CGI = √(φ × ρ); φ = global coherence, ρ = Lempel-Ziv complexity), a rate-of-change measure of the integration-complexity geometric mean. In inhaled-DMT EEG (N = 35), mac_I predicted subjective experience intensity (Spearman ρ = 0.41, p = 0.016, surrogate-validated). Five alternative rate-of-change measures (coherence alone, complexity alone, broadband power, alpha power, aperiodic slope) all failed. The formula is specific and non-replaceable. Separately, EEG microstate spatial configuration (PAT_PC1) predicted visual content type (complex vs elementary imagery; ρ = 0.56, p < 0.001), while being orthogonal to intensity. The two measures formed a pre-specified double dissociation: each predicted its target and failed to predict the other’s (Steiger’s test: p = 0.007 for the pattern arm). The dissociation did not generalise to psilocybin (N = 57, all tests null). Conclusion. mac_I is a formula-specific, surrogate-validated predictor of DMT experience intensity that dissociates from spatial content encoding. The double dissociation provides within-dataset evidence that intensity and visual content type are separable neural dimensions under DMT. This finding requires independent confirmatory replication. Keywords: consciousness, DMT, EEG, integration, complexity, microstates, psychedelic, double dissociation, mac_I

v2: Added stress test battery (§3.10): split-half reliability, microstate k-sensitivity, window-size robustness, recording duration confound check, and subscale decomposition. Added neuroanatomical characterisation of Map D (§4.4). Minor corrections to surrogate sample size clarification and outcome measure disambiguation.

Keywords

Consciousness, psychedelic, DMT, double dissociation, integration, microstates, EEG, mac_I, complexity

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green