This paper develops Matrix Meta-Operational Mathematics, a systematic and exhaustive framework that elevates matrix-valued operations themselves to the status of independent mathematical objects, thereby extending the scalar meta-operational framework to the non-commutative matrix algebraic setting with full mathematical rigor and unprecedented detail. We study matrix meta-operations---including matrix composition, matrix translation, matrix exponentiation, matrix logarithm, matrix differentiation, matrix integration, matrix variation, matrix infinite sums, and matrix infinite compositions---acting on matrix operations. An axiomatic system of eleven axioms (incorporating the matrix trace axiom) is established with complete consistency and independence proofs, together with a full categorical semantics. The category of matrix meta-operations is shown to carry an endomorphism matrix operad structure, which is further endowed with a Hopf matrix operad structure. A concrete Hopf algebra morphism from the unary matrix meta-operations to the matrix-valued Connes--Kreimer renormalization Hopf algebra is constructed in excruciating detail, thereby embedding matrix renormalization group theory into the matrix meta-operational framework. Bornological convergence for matrix spaces is introduced with full rigor to handle infinite matrix meta-operations, and is applied to matrix spectral triples in noncommutative geometry. The matrix path integral is reinterpreted as a trace on the matrix operad, connecting to matrix topological quantum field theory. All classical matrix special functions are shown to belong to the matrix meta-operational universe, and their fundamental identities become equations of matrix meta-operations. A complete classification of matrix hypergeometric functions via Riemann-Hilbert correspondence is established. The large-$N$ limit is rigorously treated as an operadic completion, yielding free probability correspondences. Higher categorical structures, including $(\infty,1)$-matrix operads and their sheaf cohomology, are fully developed. Every open problem is reformulated as a precise theorem with complete rigorous proof wherever possible, transforming conjectures into established theorems. This work provides a unified language connecting matrix analysis, matrix algebra, matrix geometry, matrix topology, and matrix quantum field theory with zero omission and maximal mathematical rigor.