Dataset of the research article "Drag reduction via separation control using plasma actuators on a truck cabin side" by Lucas Schneeberger, Stefano Discetti and Andrea Ianiro (http://doi.org/10.1063/5.0316079). We investigate the drag reduction on a heavy-duty vehicle using dielectric-barrier discharge plasma actuators located on the A-pillars. An experimental campaign is carried out on a generalized truck model, the Ground Transportation System (GTS), which is known for its lateral separation bubbles on both sides of the truck's cabin. Measurements are performed for several yaw angles up to 7.5º. Actuation is applied individually on the leeward and windward sides as well as simultaneously. Load cell measurements show that the plasma actuators effectively reduce the axial force on the GTS, with symmetric actuation achieving the highest reduction. Leeward actuation demonstrates greater control authority than the windward one; at large yaw angles the latter has a negligible effect on the axial force. Regarding side force, the leeward actuation produces a drop in its magnitude while windward actuation produces an increase. Interestingly, actuating symmetrically also augments the side force. Particle image velocimetry reveals that the plasma actuator causes a reduction in the length and width of the separation bubble on the cabin side, reducing the apparent frontal area of the truck and thus its drag. Under crosswind conditions, the stronger authority of the leeward actuator is explained by the larger separation bubble. The side force variation is driven by the net lateral suction force, which correlates with the size of the lateral recirculation regions controlled by the actuators. This activity is part of the project ACCREDITATION (Grant No TED2021-131453B-I00), funded by MICIU/AEI/ 10.13039/501100011033 and by the “European Union NextGenerationEU/PRTR”.