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Dataset . 2022
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Data sources: Datacite
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ZENODO
Dataset . 2022
License: CC BY
Data sources: ZENODO
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ZENODO
Dataset . 2022
License: CC BY
Data sources: Datacite
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ZENODO
Dataset . 2022
License: CC BY
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ZENODO
Dataset . 2026
License: CC BY
Data sources: ZENODO
ZENODO
Dataset . 2026
License: CC BY
Data sources: Datacite
ZENODO
Dataset . 2026
License: CC BY
Data sources: Datacite
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Supplementary information for 'Crustacean leg regeneration restores complex microanatomy and cell diversity' by Almazán, Çevrim et al.

Authors: Almazán, Alba; Çevrim, Çağrı; Musser, Jacob M.; Averof, Michalis; Paris, Mathilde;

Supplementary information for 'Crustacean leg regeneration restores complex microanatomy and cell diversity' by Almazán, Çevrim et al.

Abstract

Animals can regenerate complex organs, yet this frequently results in imprecise replicas of the original structure. In the crustacean Parhyale, embryonic and regenerating legs differ in gene expression dynamics but produce apparently similar mature structures. We examine the fidelity of Parhyale leg regeneration using complementary approaches to investigate microanatomy, sensory function, cellular composition and cell molecular profiles. We find that regeneration precisely replicates the complex microanatomy and spatial distribution of external sensory organs, and restores their sensory function. Single-nuclei sequencing shows that regenerated and uninjured legs are indistinguishable in terms of cell type composition and transcriptional profiles. This remarkable fidelity highlights the ability of organisms to achieve identical outcomes via distinct processes.

Keywords

regeneration, Parhyale hawaiensis, crustaceans, sensory organs, scRNA-seq, single-nuclei RNA-seq

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selected citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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