About Europe’s Research & Innovation potential is central to driving societal progress, environmental solutions and economic growth and advancing the green and digital transitions. To realise this potential, stakeholders in research and knowledge transfer must develop robust and effective Research Knowledge Valorisation Strategies that foster the circulation and re-use of research outputs while ensuring appropriate regulation through Intellectual Property rights. Addressing the European Research Area Policy Agendas (2022–2024 and 2025–2027), the Horizon Europe project IP4OS (2025–2026) provides practical guidance for an effective Valorisation approach that combines agile Intellectual Property management with the sharing of Findable, Accessible, Interoperable, and Re-usable (FAIR) research outputs (data, results, codes, etc.)—a concerted Intellectual Property–Open Science approach. Throughout the project, innovative guidance has been developed in the form of the IP4OS Toolbox, supporting European multi-professional teams (p. 1-4), researchers, Open Science Ambassadors, Knowledge & Technology Transfer Professionals, Librarians, Research Managers, Data Stewards et al., and institutions in achieving impact and value creation. The simple Knowledge Valorisation Rubric, part of the IP4OS Toolbox, provides practical guidance for developing a systematic Valorisation Strategy by breaking the process into key components and supporting the assessment of the Focus of intellectual assets (producing new or re-using existing intellectual assets) Level or conditions of re-use Timing for/of reuse. Outcome Stakeholders such as multi-professional teams can apply this Rubric in consultations with researchers, while researchers and consortia can use them to define their impact and value-creation strategies in advance._________________________________________________________________________________________________________ Other materials from the IP4OS Toolbox IP4OS Toolbox: FAIR-R²L Rubric IP4OS Toolbox: Valorisation Consultancy Form IP4OS Toolbox: Concepts, Valorisation Pathway, and Resources for IP and OS IP4OS Toolbox: Guide on Multi-professional Teams and Consultations IP4OS Toolbox: Pilot Learning Lab