Word order is a fundamental component of syntax and sentence structure that reflects a language’s typological characteristics. English and Uzbek exhibit markedly different word order patterns, with English primarily following a Subject–Verb–Object (SVO) structure, whereas Uzbek employs a Subject–Object–Verb (SOV) typology. Understanding these patterns is critical for language acquisition, translation, and cross-linguistic comparison. This paper examines the syntactic characteristics of English and Uzbek sentences, analyzes the differences and similarities in their word order, and discusses the implications for language teaching and computational linguistics. The study draws on both theoretical frameworks in generative grammar and functional approaches, supplemented with practical examples.